Sickle Cell Disease/Trait (***)

Exchange Transfusions Possible Plasmapheresis? Test used pre-op is Hb electropheresis

HbA = 97% HbS = 20-45% is severe HbC = Less severe than S

More sickling risk if > 30% HbS

4 Types of Sickle Cell Disease:

• Sickle Cell Anemia (Hgb S) • Sickle-Hemoglobin C • Sickle Beta-Plus Thalassemia • Sickle Beta-Zero Thalassemia

//(Explain the hetero vs homozygous and how it affects trait vs disease with images)